SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening고처리량 항바이러스 스크리닝을 위한 SARS-CoV-2 허용 교모세포종 세포주Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 Administered Antiviral Antiviral screen cathepsin cathepsin B cathepsin L Cell cell line cell lysis cell monolayer cells cellular cellular infection system circulation Complete contagious CPE Cytopathic effect destruction develop effective evidenced expressed expressing fused Glioblastoma implementation infection with SARS-CoV-2 Nirmatrelvir omicron Permissive preclinical study productive viral replication reduction Remdesivir replicate reported required robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spread tested TMPRSS2 U87 cell line. Vaccine variant virus wild-type virus [DOI] 10.1016/j.antiviral.2022.105342 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α v β 3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing AntibodiesSARS-CoV-2는 백신 유도 중화 항체가 있는 경우에도 α v β 3 인테그린 매개 세포내이입을 통해 인간 ACE2 음성 내피 세포를 감염시킵니다Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] absence ACE2 acute respiratory syndrome Angiogenesis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-spike antibodies antibody BNT162b2 BNT162b2 vaccine Cell clathrin conserved endocytosis Endothelial cell endothelial cell dysfunction endothelial cells enzyme Evidence expression functional gateway highlight Human human lung impair Infection inhibit SARS-CoV-2 integrin integrin-mediated Integrins Interaction Intervention Lineage maintain monoclonal antibody motif neutralize phenotype Presence Prevent productive viral replication promote Protein RBD Receptor binding domain respiratory responsible RGD motif SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants sequence Spike protein the SARS-CoV-2 the Spike the vaccine vaccination Viral viral envelope virus virus viruses αvβ3 integrin αvβ3 integrin. [DOI] 10.3390/v14040705 PMC 바로가기 [Article Type] Article
Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 InfectionLentiviral hACE2 벡터를 사용한 쥐의 SARS-CoV-2 감염 모델링은 SARS-CoV-2 감염에 대한 두 가지 면역 반응 모드를 추론합니다Article Published on 2021-12-212022-09-12 Journal: Viruses [Category] SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus Analysis angiotensin antiviral drugs applied caused contribute coronavirus COVID-19 effectors element enzyme expression Gene expression analysis generate global pandemic hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cell human cells IFNAR1 immune immune response immune responses immunogenic in vivo infected cell Infection interferon interferon receptor knock-out lack Lentiviral vector lentiviral vectors lentivirus lung Lung disease mice Mild mode modeling mouse model pathology productive viral replication receptor response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling stimulate Strains supported susceptible transgenic mice triggered Type I IFN Vaccine development vector virus wild-type [DOI] 10.3390/v14010011 PMC 바로가기 [Article Type] Article
Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응Research Article Published on 2021-09-022022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘, [키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses [DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epitheliumSARS-CoV-2는 인간 성인 기증자의 눈과 hESC 유래 안구 상피를 감염시킵니다.Article Published on 2021-07-012022-09-11 Journal: Cell Stem Cell [Category] SARS, 치료기술, [키워드] ACE2 aerosol transmission Analysis antigen expression cadaver caused Cell Cornea COVID-19 COVID-19 patient Culture Donor Ex vivo eye infect infected cell infected cells Infection interferon interferon signaling life limbus mechanism NF-κB ocular Ocular surface organoid cultures portal Post-mortem productive viral replication regions robust SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pandemic scRNA-seq Spread stem cells stem cells. These data thought tissue Transmission viral entry viral particle Viral particles while [DOI] 10.1016/j.stem.2021.04.028 PMC 바로가기 [Article Type] Article
Integrated approaches to reveal mechanisms by which RNA viruses reprogram the cellular environmentRNA 바이러스가 세포 환경을 재프로그래밍하는 메커니즘을 밝히기 위한 통합 접근법Review Published on 2020-11-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory illness acute respiratory illnesses AIDS approach biochemical Cancer cancers cellular complex contribute description Each favor feature functional genetic material hallmark host cells human disease human diseases infecting infections information Interaction International long-lasting mechanism multifunctional outbreak pathogen Pathogens physicochemical productive viral replication Proteins Reactions respiratory RNA RNA genome RNA genomes RNA virus RNA viruses storage T cell T cell lymphoma therapeutic targets threat Viral viral family viral RNA genome virus Virus-host interactions viruses [DOI] 10.1016/j.ymeth.2020.06.013 PMC 바로가기 [Article Type] Review
Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesisReview Published on 2015-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] affected animal models antagonistic antiviral cytokine Apoptosis autopsy study Brain cell interaction coronavirus dendritic cells dissemination Epidemic epithelial cells Ex vivo help Human human lung human macrophage human primary cell implication IMPROVE in vitro induce infect infection control Infectious virus lack mechanism MERS MERS patient MERS-CoV MERS-CoV infection Middle East multiple organ organ Pathogenesis productive viral replication proinflammatory public health replicate research finding respiratory respiratory epithelial cell respiratory syndrome coronavirus severe respiratory infection suggested Support susceptible T cell These cells tissue tropism tissues Treatment triggering Viral RNA virus [DOI] 10.1186/s12985-015-0446-6 PMC 바로가기 [Article Type] Review